Counteracting selection for antibiotic-resistant bacteria

SCREENING FOR ANTIBIOTIC RESISTANT BACTERIA IN URINE SAMPLES

Chronic urinary tract infections are often caused by antibiotic resistant bacteria. In some of these cases, prediction of the most effective antibiotic (s) may urgently be needed. This can not be achieved unless the nature and patterns of the resistance to antibiotics among the pathogenic bacteria has been described earlier. The urine samples that reached the laboratory of Shaheed Mustafa K...

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in many environments plays in selection remains largely unclear. Here we show usi...

New antibiotics for antibiotic-resistant bacteria

The need for new antibiotics to effectively treat antibiotic-resistant infections remains unfulfilled. Despite the well-publicised concern over this issue, only two novel antibiotic classes have been introduced in the past 20 years alongside several new agents of existing classes. Accordingly, the current antibiotic armoury remains inadequate to meet the challenges posed by resistance today. Mo...

Microbial approaches for targeting antibiotic‐resistant bacteria

Antibiotic resistant bacterial infections are a global public health challenge that has been increasing in severity and scope for the last few decades. Without creative solutions to this problem, treatment of injuries and infections will become progressively more challenging. A better understanding of the human microbiome has led to a new appreciation for the role commensal microbes play in pro...

Impacts of Antibiotic-Resistant Bacteria